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Immunology

Cytotoxic T cells that escape exhaustion

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T cells of the immune system mount antiviral responses, but if a response fails, a chronic viral infection can develop. It now seems that a T-cell subset in lymphoid immune tissues can control chronic infection. See Letters p.412 & p.417

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Figure 1: A T-cell subset that targets chronic viral infection.

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References

  1. 1

    Im, S. J. et al. Nature 537, 417–421 (2016).

    CAS  ADS  Article  Google Scholar 

  2. 2

    He, R. et al. Nature 537, 412–416 (2016).

    CAS  ADS  Article  Google Scholar 

  3. 3

    Leong, Y. A. et al. Nature Immunol. http://dx.doi.org/10.1038/ni.3543 (2016).

  4. 4

    Cui, W. & Kaech, S. M. Immunol. Rev. 236, 151–166 (2010).

    CAS  Article  Google Scholar 

  5. 5

    Fukazawa, Y. et al. Nature Med. 21, 132–139 (2015).

    CAS  Article  Google Scholar 

  6. 6

    Tangye, S. G., Ma, C. S., Brink, R. & Deenick, E. K. Nature Rev. Immunol. 13, 412–426 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Crotty, S. Immunity 41, 529–542 (2014).

    CAS  Article  Google Scholar 

  8. 8

    Crotty, S. Annu. Rev. Immunol. 29, 621–663 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Forster, R., Emrich, T., Kremmer, E. & Lipp, M. Blood 84, 830–840 (1994).

    CAS  Article  Google Scholar 

  10. 10

    Quigley, M. F., Gonzalez, V. D., Granath, A., Andersson, J. & Sandberg, J. K. Eur. J. Immunol. 37, 3352–3362 (2007).

    CAS  Article  Google Scholar 

  11. 11

    Wherry, E. J. & Kurachi, M. Nature Rev. Immunol. 15, 486–499 (2015).

    CAS  Article  Google Scholar 

  12. 12

    Choi, Y. S. et al. Nature Immunol. 16, 980–990 (2015).

    CAS  Article  Google Scholar 

  13. 13

    Shaw, L. A. et al. Nature Immunol. 17, 834–843 (2016).

    CAS  Article  Google Scholar 

  14. 14

    Topalian, S. L., Drake, C. G. & Pardoll, D. M. Cancer Cell 27, 450–461 (2015).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Cindy S. Ma or Stuart G. Tangye.

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Ma, C., Tangye, S. Cytotoxic T cells that escape exhaustion. Nature 537, 312–314 (2016). https://doi.org/10.1038/nature19428

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