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Suffocation of gene expression

If a tumour outgrows its blood supply, oxygen levels in its cells decrease. It emerges that this change can alter gene expression by limiting the activity of TET enzymes, which remove methyl groups from DNA. See Article p.63

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Figure 1: Reducing TET activity through hypoxia.


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Correspondence to Dan Ye or Yue Xiong.

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Ye, D., Xiong, Y. Suffocation of gene expression. Nature 537, 42–43 (2016).

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