Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Catalytic spliceosome captured

Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Spliceosomal processing of RNA transcripts.
Figure 2: Model of the catalytically active spliceosome structure.


  1. See all news & views


  1. Galej, W. P. et al. Nature 537, 197–201 (2016).

    ADS  CAS  Article  Google Scholar 

  2. Fica, S. M. et al. Nature 503, 229–234 (2013).

    ADS  CAS  Article  Google Scholar 

  3. Nogales, E. Nature Methods 13, 24–27 (2016).

    CAS  Article  Google Scholar 

  4. Agafonov, D. E. et al. Science 351, 1416–1420 (2016).

    ADS  CAS  Article  Google Scholar 

  5. Nguyen, T. H. et al. Nature 530, 298–302 (2016).

    ADS  CAS  Article  Google Scholar 

  6. Wan, R. et al. Science 351, 466–475 (2016).

    ADS  CAS  Article  Google Scholar 

  7. Yan, C. et al. Science 349, 1182–1191 (2015).

    ADS  CAS  Article  Google Scholar 

  8. Yan, C., Wan, R., Bai, R., Huang, G. & Shi, Y. Science http://dx.doi/org/10.1126/science.aag0291 (2016).

  9. Wan, R., Yan, C., Bai, R., Huang, G. & Shi, Y. Science (2016).

  10. Yoshida, K. et al. Nature 478, 64–69 (2011).

    ADS  CAS  Article  Google Scholar 

  11. Newby, M. I. & Greenbaum, N. L. Nature Struct. Mol. Biol. 9, 958–965 (2002).

    CAS  Article  Google Scholar 

  12. Schmeing, T. M. & Ramakrishnan, V. Nature 461, 1234–1242 (2009).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Brian Kosmyna or Charles C. Query.

Related links

Related links

Related links in Nature Research

Structural biology: Lariat lessons

Biochemistry: Metal ghosts in the splicing machine

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kosmyna, B., Query, C. Catalytic spliceosome captured. Nature 537, 175–176 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing