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Structural biology

Catalytic spliceosome captured

Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197

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Figure 1: Spliceosomal processing of RNA transcripts.
Figure 2: Model of the catalytically active spliceosome structure.

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References

  1. Galej, W. P. et al. Nature 537, 197–201 (2016).

    ADS  CAS  Article  Google Scholar 

  2. Fica, S. M. et al. Nature 503, 229–234 (2013).

    ADS  CAS  Article  Google Scholar 

  3. Nogales, E. Nature Methods 13, 24–27 (2016).

    CAS  Article  Google Scholar 

  4. Agafonov, D. E. et al. Science 351, 1416–1420 (2016).

    ADS  CAS  Article  Google Scholar 

  5. Nguyen, T. H. et al. Nature 530, 298–302 (2016).

    ADS  CAS  Article  Google Scholar 

  6. Wan, R. et al. Science 351, 466–475 (2016).

    ADS  CAS  Article  Google Scholar 

  7. Yan, C. et al. Science 349, 1182–1191 (2015).

    ADS  CAS  Article  Google Scholar 

  8. Yan, C., Wan, R., Bai, R., Huang, G. & Shi, Y. Science http://dx.doi/org/10.1126/science.aag0291 (2016).

  9. Wan, R., Yan, C., Bai, R., Huang, G. & Shi, Y. Science http://dx.doi.org/10.1126/science.aag2235 (2016).

  10. Yoshida, K. et al. Nature 478, 64–69 (2011).

    ADS  CAS  Article  Google Scholar 

  11. Newby, M. I. & Greenbaum, N. L. Nature Struct. Mol. Biol. 9, 958–965 (2002).

    CAS  Article  Google Scholar 

  12. Schmeing, T. M. & Ramakrishnan, V. Nature 461, 1234–1242 (2009).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Brian Kosmyna or Charles C. Query.

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Kosmyna, B., Query, C. Catalytic spliceosome captured. Nature 537, 175–176 (2016). https://doi.org/10.1038/nature19422

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