Extended Data Figure 1: LCMV GP276-specific CD8+ T cells also consist of CXCR5+ and CXCR5− CD8+ T-cell subsets during chronic infection. | Nature

Extended Data Figure 1: LCMV GP276-specific CD8+ T cells also consist of CXCR5+ and CXCR5 CD8+ T-cell subsets during chronic infection.

From: Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Extended Data Figure 1

a, Phenotypic analysis of GP276-specific CD8+ T cells in the spleens of immune mice that had cleared an acute LCMV Armstrong infection or mice that were chronically infected with LCMV clone 13 (day 30 after infection (p.i.)). FACS plots showing CXCR5 expression in combination with the indicated markers are gated on GP276-tetramer+ CD8+ T cells. b, Longitudinal analysis of the numbers of GP276-specific CXCR5+Tim-3 and CXCR5Tim-3+ CD8+ T cells in the spleen at the indicated time after infection. LCMV titers in the serum are shown as the shaded yellow area. Graph shows the mean ± s.e.m. Data are the average of 8 mice from two experiments per time point (total n = 48). c, Phenotypic characterization of CXCR5+ and CXCR5 GP276-specific CD8+ T cells in the spleen of chronically infected mice (>45 days p.i.).

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