Extended Data Figure 10: Enhanced conversion of CXCR5+Tim-3−CD8+ T cells to Tim-3+CD8+ T cells after PD-1 blockade. | Nature

Extended Data Figure 10: Enhanced conversion of CXCR5+Tim-3CD8+ T cells to Tim-3+CD8+ T cells after PD-1 blockade.

From: Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy

Extended Data Figure 10

a, Sorted PD-1+CXCR5+Tim-3 and PD-1+CXCR5Tim-3+ CD8+ T cells isolated from CD45.2+ chronically infected mice (>45 days p.i.) were adoptively transferred into infection-matched CD45.1+ recipient mice, followed by treatment with anti-PD-L1 antibody. b, Phenotypic analysis of sorted donor CD8+ T-cell subsets before transfer and 14 days after the transfer followed by PD-1 blockade. Data are representative of 2 experiments (total n = 5, 7, or 9 mice per group).

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