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Cell biology

The TORC1 pathway to protein destruction


A study of the proteasome — a protein-degradation complex — reveals an evolutionarily conserved pathway that acts through the protein kinase TORC1 to adjust proteasome levels in response to cellular needs. See Letter p.184

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Figure 1: Evolutionarily conserved regulation of proteasome abundance.


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Correspondence to Lynne Chantranupong or David M. Sabatini.

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Chantranupong, L., Sabatini, D. The TORC1 pathway to protein destruction. Nature 536, 155–156 (2016).

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