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Neuroscience

Nanocolumns at the heart of the synapse

A nanocolumn spans the synaptic cleft between neurons, connecting regions of neurotransmitter molecule release and capture. This discovery informs on mechanisms of synaptic organization and regulation. See Letter p.210

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Figure 1: Architecture of a synapse.

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References

  1. 1

    Chia, P. H., Li, P. & Shen, K. J. Cell Biol. 203, 11–22 (2013).

    CAS  Article  Google Scholar 

  2. 2

    Tang, A.-H. et al. Nature 536, 210–214 (2016).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Ackermann, F., Waites, C. L. & Garner, C. C. EMBO Rep. 16, 923–938 (2015).

    CAS  Article  Google Scholar 

  4. 4

    Maglione, M. & Sigrist, S. J. Nature Neurosci. 16, 790–797 (2013).

    CAS  Article  Google Scholar 

  5. 5

    Matkovic, T. et al. J. Cell Biol. 202, 667–683 (2013).

    CAS  Article  Google Scholar 

  6. 6

    Fernández-Busnadiego, R. et al. J. Cell Biol. 201, 725–740 (2013).

    Article  Google Scholar 

  7. 7

    Deng, L., Kaeser, P. S., Xu, W. & Südhof, T. C. Neuron 69, 317–331 (2011).

    CAS  Article  Google Scholar 

  8. 8

    Han, Y., Kaeser, P. S., Südhof, T. C. & Schneggenburger, R. Neuron 69, 304–316 (2011).

    CAS  Article  Google Scholar 

  9. 9

    Rust, M. J., Bates, M. & Zhuang, X. Nature Meth. 3, 793–795 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Nair, D. et al. J. Neurosci. 33, 13204–13224 (2013).

    CAS  Article  Google Scholar 

  11. 11

    MacGillavry, H. D., Song, Y., Raghavachari, S. & Blanpied, T. A. Neuron 78, 615–622 (2013).

    CAS  Article  Google Scholar 

  12. 12

    Kaeser, P. S. et al. Cell 144, 282–295 (2011).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Stephan J. Sigrist or Astrid G. Petzoldt.

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Sigrist, S., Petzoldt, A. Nanocolumns at the heart of the synapse. Nature 536, 151–152 (2016). https://doi.org/10.1038/nature18917

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