Dead cells are usually removed through their ingestion and destruction by other cells. A study of plaque deposits in arteries shows that dying cells in plaques display a 'don't-eat-me' signal that blocks their removal. See Letter p.86
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
World Health Organization. http://www.who.int/mediacentre/factsheets/fs310/en (2014).
Virmani, R., Burke, A. P., Kolodgie, F. D. & Farb, A. J. Interv. Cardiol. 15, 439–446 (2002).
Kojima, Y. et al. Nature 536, 86–90 (2016).
Thorp, E., Subramanian, M. & Tabas, I. Eur. J. Immunol. 41, 2515–2518 (2011).
Arandjelovic, S. & Ravichandran, K. S. Nature Immunol. 16, 907–917 (2015).
Schrijvers, D. M., De Meyer, G. R., Kockx, M. M., Herman, A. G. & Martinet, W. Arterioscler. Thromb. Vasc. Biol. 25, 1256–1261 (2005).
Lin, J. et al. Cell Rep. 3, 200–210 (2013).
Greenlee-Wacker, M. C. et al. J. Immunol. 192, 4709–4717 (2014).
Kojima, Y. et al. J. Clin. Invest. 124, 1083–1097 (2014).
Thorp, E. et al. J. Biol Chem. 286, 33335–33344 (2011).
Garbin, U. et al. Cardiovasc. Res. 97, 125–133 (2013).
Tabas, I. & Glass, C. K. Science 339, 166–172 (2013).
Liu, J. et al. PLoS One 10, e0137345 (2015).
Serhan, C. N. Nature 510, 92–101 (2014).
Fredman, G. et al. Sci. Transl. Med. 7, 275ra20 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Tabas, I. Death-defying plaque cells. Nature 536, 32–33 (2016). https://doi.org/10.1038/nature18916
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature18916