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Physiology

Pancreatic β-cell heterogeneity revisited

Two analyses of insulin-producing β-cells reveal differences in what has long been considered a homogeneous population. These differences might reflect changes during maturation or ageing, or distinct cell lineages. See Letter p.430

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Figure 1: Separating β-cell subtypes.

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References

  1. Jermendy, A. et al. Diabetologia 54, 594–604 (2011).

    Article  CAS  Google Scholar 

  2. Blum, B. et al. Nature Biotechnol. 30, 261–264 (2012).

    Article  CAS  Google Scholar 

  3. Salomon, D. & Meda, P. Exp. Cell Res. 162, 507–520 (1986).

    Article  CAS  Google Scholar 

  4. Pipeleers, D. G. Diabetes 41, 777–781 (1992).

    Article  CAS  Google Scholar 

  5. Bader, E. M. A. et al. Nature 535, 430–434 (2016).

    Article  CAS  ADS  Google Scholar 

  6. Dorrell, C. S. J. et al. Nature Commun. http://dx.doi.org/10.1038/ncomms11756 (2016).

  7. Katsuta, H. et al. Endocrinology 153, 5180–5187 (2012).

    Article  CAS  Google Scholar 

  8. Peng, S. W. et al. Endocrinology 150, 3058–3066 (2009).

    Article  CAS  Google Scholar 

  9. Tschen, S. I., Dhawan, S., Gurlo, T. & Bhushan, A. Diabetes 58, 1312–1320 (2009).

    Article  CAS  Google Scholar 

  10. Van Schravendijk, C. F., Kiekens, R. & Pipeleers, D. G. J. Biol. Chem. 267, 21344–21348 (1992).

    CAS  PubMed  Google Scholar 

  11. Schuit, F. C., In' t Veld, P. A. & Pipeleers, D. G. Proc. Natl Acad. Sci. USA 85, 3865–3869 (1988).

    Article  CAS  ADS  Google Scholar 

  12. Bosco, D. & Meda, P. Endocrinology 129, 3157–3166 (1991).

    Article  CAS  Google Scholar 

  13. Hiriart, M. & Ramirez-Medeles, M. C. Endocrinology 128, 3193–3198 (1991).

    Article  CAS  Google Scholar 

  14. Ling, Z., Wang, Q., Stangé, G., In't Veld, P. & Pipeleers, D. Diabetes 55, 78–85 (2006).

    Article  CAS  Google Scholar 

  15. Karaca, M. et al. PLoS ONE 4, e5555 (2009).

    Article  ADS  Google Scholar 

  16. Dorrell, C. et al. Diabetologia 54, 2832–2844 (2011).

    Article  CAS  Google Scholar 

  17. Weir, G. C. & Bonner-Weir, S. Ann. NY Acad. Sci. 1281, 92–105 (2013).

    Article  CAS  ADS  Google Scholar 

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Correspondence to Susan Bonner-Weir.

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Bonner-Weir, S., Aguayo-Mazzucato, C. Pancreatic β-cell heterogeneity revisited. Nature 535, 365–366 (2016). https://doi.org/10.1038/nature18907

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