Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Diabetes

Still a geneticist's nightmare

The largest DNA-sequencing study of type 2 diabetes conducted so far concludes that, contrary to expectation, low-frequency and rare genetic variants do not contribute significantly to disease risk. See Article p.41

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Notes

  1. See all news & views

References

  1. Rewers, M. & Hamman, R. F. in Diabetes in America 2nd edn, Ch. 9, 179–220 (NIH, 1995).

    Google Scholar 

  2. Morris, A. P. et al. Nature Genet. 44, 981–990 (2012).

    CAS  Article  Google Scholar 

  3. Fuchsberger, C. et al. Nature 536, 41–47 (2016).

    ADS  CAS  Article  Google Scholar 

  4. Steinthorsdottir, V. et al. Nature Genet. 46, 294–298 (2014).

    CAS  Article  Google Scholar 

  5. Cho, Y. S. et al. Nature Genet. 44, 67–72 (2012).

    CAS  Article  Google Scholar 

  6. Ma, R. C. W. et al. Diabetologia 56, 1291–1305 (2013).

    CAS  Article  Google Scholar 

  7. Neel, J. V. in The Genetics of Diabetes Mellitus (eds Creutzfeldt, W., Köbberling, J. & Neel, J. V.) 1–11 (Springer, 1976).

    Book  Google Scholar 

  8. Cohen, J. C., Boerwinkle, E., Mosley, T. H. Jr & Hobbs, H. H. N. Engl. J. Med. 354, 1264–1272 (2006).

    CAS  Article  Google Scholar 

  9. Bergman, R. N. et al. Diabetes 52, 2168–2174 (2003).

    CAS  Article  Google Scholar 

  10. Zeggini, E., Gloyn, A. L. & Hansen, T. Diabetologia 59, 938–941 (2016)

    Article  Google Scholar 

  11. Blangero, J. & Kent, J. W. Jr in Genetic and Molecular Aspects of Sport Performance (eds Bouchard, C. & Hoffman, E. P.) 33–45 (Wiley-Blackwell, 2011).

    Google Scholar 

  12. Lange, L. A. et al. Am. J. Hum. Genet. 94, 233–245 (2014).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Stephen S. Rich.

Related links

Related links

Related links in Nature Research

Genomics: Resident risks

Genetics: Closing the distance on obesity culprits

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Rich, S. Still a geneticist's nightmare. Nature 536, 37–38 (2016). https://doi.org/10.1038/nature18906

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature18906

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing