The largest DNA-sequencing study of type 2 diabetes conducted so far concludes that, contrary to expectation, low-frequency and rare genetic variants do not contribute significantly to disease risk. See Article p.41
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Rich, S. Still a geneticist's nightmare. Nature 536, 37–38 (2016). https://doi.org/10.1038/nature18906
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DOI: https://doi.org/10.1038/nature18906
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