Extended Data Figure 8: Effect of phase-specific PV manipulation on dmPFC co-firing activity. | Nature

Extended Data Figure 8: Effect of phase-specific PV manipulation on dmPFC co-firing activity.

From: Prefrontal neuronal assemblies temporally control fear behaviour

Extended Data Figure 8

a, b, Top: corrected pairwise co-firing for pairs of dmPFC neurons recorded in mice infected with ChR2 or GFP during stimulation in the ascending (a, ChR2, n = 2,877 pairs; GFP, n = 2,067 pairs) or descending (b, ChR2, n = 2,067 pairs; GFP, n = 2,282 pairs) phase of 4 Hz oscillations. Bottom: averaged delta-corrected pairwise co-firing activity (delta = ChR2 minus GFP) as a function of 4 Hz phase (one sample t-test with Bonferroni correction, hypothetical mean = 0, **P < 0.01, ***P < 0.001). c, d, Top: corrected pairwise co-firing for pairs of dmPFC neurons recorded in mice infected with ArchT or GFP during stimulation in the ascending (a, ArchT, n = 2,389 pairs; GFP, n = 2,542 pairs) or descending (b, ArchT, n = 3,122 pairs; GFP, n = 2,282 pairs) phase of 4 Hz oscillations. Bottom: averaged delta-corrected pairwise co-firing activity (delta = ArchT minus GFP) as a function of 4 Hz phase (one-sample t-test with Bonferroni correction, hypothetical mean = 0, *P < 0.05, **P < 0.01, ***P < 0.001). Error bars, mean ± s.e.m.

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