Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Seeds of neuroendocrine doubt

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout


  1. Jaunmuktane, Z. et al. Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy. Nature 525, 247–250 (2015)

    Article  CAS  ADS  PubMed  Google Scholar 

  2. Milner, R. D. et al. Experience with human growth hormone in Great Britain: the report of the MRC Working Party. Clin. Endocrinol. 11, 15–38 (1979)

    Article  CAS  Google Scholar 

  3. Brown, P. et al. Iatrogenic Creutzfeldt–Jakob disease, final assessment. Emerg. Infect. Dis. 18, 901–907 (2012)

    Article  PubMed  PubMed Central  Google Scholar 

  4. Buchanan, C. R., Preece, M. A. & Milner, R. D. Mortality, neoplasia, and Creutzfeldt-Jakob disease in patients treated with human pituitary growth hormone in the United Kingdom. Br. Med. J. 302, 824–828 (1991)

    Article  CAS  Google Scholar 

  5. Buchanan, C. R., Law, C. M. & Milner, R. D. Growth hormone in short, slowly growing children and those with Turner’s syndrome. Arch. Dis. Child. 62, 912–916 (1987)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Rudge, P. et al. Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years. Brain 138, 3386–3399 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  7. Nyberg, F. & Hallberg, M. Growth hormone and cognitive function. Nat. Rev. Endocrinol. 9, 357–365 (2013)

    Article  CAS  PubMed  Google Scholar 

  8. Webb, E. A. et al. Effect of growth hormone deficiency on brain structure, motor function and cognition. Brain 135, 216–227 (2012)

    Article  PubMed  Google Scholar 

  9. Falleti, M. G., Maruff, P., Burman, P. & Harris, A. The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: a meta-analysis of the current literature. Psychoneuroendocrinology 31, 681–691 (2006)

    Article  CAS  PubMed  Google Scholar 

  10. Rose, S. R. & Auble, B. A. Endocrine changes after pediatric traumatic brain injury. Pituitary 15, 267–275 (2012)

    Article  CAS  PubMed  Google Scholar 

  11. Graham, D. I., Gentleman, S. M., Lynch, A. & Roberts, G. W. Distribution of beta-amyloid protein in the brain following severe head injury. Neuropathol. Appl. Neurobiol. 21, 27–34 (1995)

    Article  CAS  PubMed  Google Scholar 

  12. Westmark, C. J. What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders. Mol. Psychiatry 18, 425–434 (2013)

    Article  CAS  PubMed  Google Scholar 

  13. Carel, J. C. et al. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. J. Clin. Endocrinol. Metab. 97, 416–425 (2012)

    Article  CAS  PubMed  Google Scholar 

  14. Poidvin, A. et al. Growth hormone treatment for childhood short stature and risk of stroke in early adulthood. Neurology 83, 780–786 (2014)

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations



C.F. wrote the article. G.P.S. contributed to writing the article. J.H.C., M.S., A.P.G. and R.L. revised the manuscript and contributed to its content.

Corresponding author

Correspondence to Claire Feeney.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Feeney, C., Scott, G., Cole, J. et al. Seeds of neuroendocrine doubt. Nature 535, E1–E2 (2016).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing