Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

When sperm meets egg

Sperm–egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins separately and in complex provides insight into the recognition process and the subsequent sperm–egg fusion. See Letters p.562 & p.566

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Juno stabilizes the Izumo1 hinge.


  1. See all news & views


  1. Aydin, H., Sultana, A., Li, S., Thavalingam, A. & Lee, J. E. Nature 534, 562–565 (2016).

    Article  ADS  CAS  Google Scholar 

  2. Ohto, U. et al. Nature 534, 566–569 (2016).

    Article  ADS  CAS  Google Scholar 

  3. Krauchunas, A. R., Marcello, M. R. & Singson, A. Mol. Reprod. Dev. 83, 376–386 (2016).

    Article  CAS  Google Scholar 

  4. Okabe, M. Development 140, 4471–4479 (2013).

    Article  CAS  Google Scholar 

  5. Inoue, N., Ikawa, M., Isotani, A. & Okabe, M. Nature 434, 234–238 (2005).

    Article  ADS  CAS  Google Scholar 

  6. Bianchi, E., Doe, B., Goulding, D. & Wright, G. J. Nature 508, 483–487 (2014).

    Article  ADS  CAS  Google Scholar 

  7. Han, L. et al. Curr. Biol. 26, R100–R101 (2016).

    Article  CAS  Google Scholar 

  8. Kato, K. et al. Nature Commun. (2016).

  9. Chen, C. et al. Nature 500, 486–489 (2013).

    Article  ADS  CAS  Google Scholar 

  10. Wibowo, A. S. et al. Proc. Natl Acad. Sci. USA 110, 15180–15188 (2013).

    Article  ADS  CAS  Google Scholar 

  11. Yanagimachi, R., Yanagimachi, H. & Rogers, B. J. Biol. Reprod. 15, 471–476 (1976).

    Article  CAS  Google Scholar 

  12. Inoue, N., Hagihara, Y., Wright, D., Suzuki, T. & Wada, I. Nature Commun. 6, 8858 (2015).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Karsten Melcher.

Related links

Related links

Related links in Nature Research

Developmental biology: Sperm–egg fusion unscrambled

Reproductive biology: Sperm protein finds its mate

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Melcher, K. When sperm meets egg. Nature 534, 484–485 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing