Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Gene regulation in transition

An in-depth analysis of a close relative of animals, Capsaspora owczarzaki, provides clues to the changes in gene regulation that occurred during the transition to multicellularity.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Evolution of gene-regulatory mechanisms.


  1. See all news & views


  1. Knoll, A. H. Annu. Rev. Earth Planet. Sci. 39, 217–239 (2011).

    Article  ADS  CAS  Google Scholar 

  2. Sebé-Pedrós, A. et al. Cell 165, 1224–1237 (2016).

    Article  Google Scholar 

  3. Erwin, D. H. Biol. J. Linn. Soc. 50, 255–274 (1993).

    Article  Google Scholar 

  4. Richter, D. J. & King, N. Annu. Rev. Genet. 47, 509–537 (2013).

    Article  Google Scholar 

  5. Levine, M., Cattoglio, C. & Tjian, R. Cell 157, 13–25 (2014).

    Article  CAS  Google Scholar 

  6. Sebé-Pedrós, A. et al. eLife 2, e01287 (2013).

    Article  Google Scholar 

  7. Lolas, M., Valenzuela, P. D. T., Tjian, R. & Liu, Z. Proc. Natl Acad. Sci. USA 111, 4478–4483 (2014).

    Article  ADS  CAS  Google Scholar 

  8. Hurlin, P. J. Cold Spring Harb. Perspect. Med. 3, a014332 (2013).

    Article  Google Scholar 

  9. Lenhard, B., Sandelin, A. & Carninci, P. Nature Rev. Genet. 13, 233–245 (2012).

    Article  CAS  Google Scholar 

  10. Levin, T. C., Greaney, A. J., Wetzel, L. & King, N. eLife 3, e04070 (2014).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to David S. Booth or Nicole King.

Related links

Related links

Related links in Nature Research

Evolutionary biology: Excitation over jelly nerves

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Booth, D., King, N. Gene regulation in transition. Nature 534, 482–483 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing