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Cell reprogramming

Brain versus brawn

Nature volume 534, pages 332–333 (2016)Cite this article

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The mechanisms that underlie enforced transitions between mature cell lineages are poorly understood. Profiling single skin cells that are induced to become neurons reveals that, unexpectedly, they often become muscle. See Letter p.391

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Figure 1: A tug-of-war between cell types.

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References

  1. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  2. Davis, R. L., Weintraub, H. & Lassar, A. B. Cell 51, 987–1000 (1987).

    Article  CAS  Google Scholar 

  3. Feng, R. et al. Proc. Natl Acad. Sci. USA 105, 6057–6062 (2008).

    Article  ADS  CAS  Google Scholar 

  4. Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).

    Article  ADS  CAS  Google Scholar 

  5. Treutlein, B. et al. Nature 534, 391–395 (2016).

    Article  ADS  Google Scholar 

  6. Graf, T. Cell Stem Cell 9, 504–516 (2011).

    Article  CAS  Google Scholar 

  7. Chanda, S. et al. Stem Cell Rep. 3, 282–296 (2014).

    Article  CAS  Google Scholar 

  8. Shapiro, E., Biezuner, T. & Linnarsson, S. Nature Rev. Genet. 14, 618–630 (2013).

    Article  CAS  Google Scholar 

  9. Cheloufi, S. et al. Nature 528, 218–224 (2015).

    Article  ADS  CAS  Google Scholar 

  10. Yang, B. X. et al. Cell 163, 230–245 (2015).

    Article  CAS  Google Scholar 

  11. Iwafunchi-Doi, M. & Zaret, K. S. Genes Dev. 28, 2679–2692 (2014).

    Article  Google Scholar 

  12. Black, B. L. & Olson, E. N. Annu. Rev. Cell Dev. Biol. 14, 167–196 (1998).

    Article  CAS  Google Scholar 

  13. Morris, S. A. et al. Cell 158, 889–902 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Bruno Di Stefano and Konrad Hochedlinger are in the Department of Molecular Biology, and in the Department of Stem Cell and Regenerative Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA, Harvard University and Harvard Medical School, and the Harvard Stem Cell Institute, Cambridge, Massachusetts.,

    Bruno Di Stefano & Konrad Hochedlinger

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  1. Bruno Di Stefano
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  2. Konrad Hochedlinger
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Correspondence to Konrad Hochedlinger.

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Di Stefano, B., Hochedlinger, K. Brain versus brawn. Nature 534, 332–333 (2016). https://doi.org/10.1038/nature18444

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