Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Immunotherapy

Cancer vaccine triggers antiviral-type defences

An immunotherapy approach targets nanoparticles to dendritic cells of the immune system, leading to an antitumour immune response with antiviral-like features. Initial clinical tests of this approach show promise. See Letter p.396

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: An antitumour nanoparticle vaccine.

Notes

  1. See all news & views

References

  1. Kranz, L. M. et al. Nature 534, 396–401 (2016).

    Article  ADS  Google Scholar 

  2. Joyce, J. A. & Fearon, D. T. Science 348, 74–80 (2015).

    Article  CAS  ADS  Google Scholar 

  3. Palucka, K. & Banchereau, J. Nature Rev. Cancer 12, 265–277 (2012).

    Article  CAS  Google Scholar 

  4. Tel, J. et al. Cancer Res. 73, 1063–1075 (2013).

    Article  CAS  Google Scholar 

  5. Tacken, P. J., de Vries, I. J., Torensma, R. & Figdor, C. G. Nature Rev. Immunol. 7, 790–802 (2007).

    Article  CAS  Google Scholar 

  6. Bonifaz, L. C. et al. J. Exp. Med. 196, 1627–1638 (2002).

    Article  CAS  Google Scholar 

  7. Bonifaz, L. C. et al. J. Exp. Med. 199, 815–824 (2004).

    Article  CAS  Google Scholar 

  8. Tacken, P. J. et al. Blood 106, 1278–1285 (2005).

    Article  CAS  Google Scholar 

  9. Cruz, L. J. et al. J. Control. Release 144, 118–126 (2010).

    Article  CAS  Google Scholar 

  10. https://clinicaltrials.gov/ct2/results?term=dec-205&Search=Search

  11. Kuhn, A. N. et al. Gene Ther. 17, 961–971 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Jolanda De Vries or Carl Figdor.

Related links

Related links

Related links in Nature Research

Autoimmunity: Antigen-specific immunotherapy

Cancer immunotherapy: Dendritic-cell vaccines on the move

Cancer treatment: The killer within

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

De Vries, J., Figdor, C. Cancer vaccine triggers antiviral-type defences. Nature 534, 329–331 (2016). https://doi.org/10.1038/nature18443

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature18443

This article is cited by

Search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer