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Pumping persisters

The finding that antibiotics are pumped out of drug-tolerant bacterial cells by the TolC protein complex provides insight into how some cells, known as persisters, survive in the face of antibiotic treatments.

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Figure 1: A subpopulation in efflux.


  1. 1.

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  1. 1

    Bigger, J. W. Lancet ii, 497–500 (1944).

    Article  Google Scholar 

  2. 2

    Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622–1625 (2004).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Maisonneuve, E., Castro-Camargo, M. & Gerdes, K. Cell 154, 1140–1150 (2013).

    CAS  Article  Google Scholar 

  4. 4

    Veening, J.-W., Smits, W. K. & Kuipers, O. P. Annu. Rev. Microbiol. 62, 193–210 (2008).

    CAS  Article  Google Scholar 

  5. 5

    Pu, Y. et al. Mol. Cell 62, 284–294 (2016).

    CAS  Article  Google Scholar 

  6. 6

    Maisonneuve, E., Shakespeare, L. J., Jørgensen, M. G. & Gerdes, K. Proc. Natl Acad. Sci. USA 108, 13206–13211 (2011).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Helaine, S. et al. Science 343, 204–208 (2014).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Verstraeten, N. et al. Mol. Cell. 59, 9–21 (2015).

    CAS  Article  Google Scholar 

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Correspondence to Kenn Gerdes.

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Gerdes, K., Semsey, S. Pumping persisters. Nature 534, 41–42 (2016).

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