The finding that antibiotics are pumped out of drug-tolerant bacterial cells by the TolC protein complex provides insight into how some cells, known as persisters, survive in the face of antibiotic treatments.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells
Scientific Reports Open Access 15 April 2019
-
Persister Cells – a Plausible Outcome of Neutral Coevolutionary Drift
Scientific Reports Open Access 25 September 2018
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Bigger, J. W. Lancet ii, 497–500 (1944).
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L. & Leibler, S. Science 305, 1622–1625 (2004).
Maisonneuve, E., Castro-Camargo, M. & Gerdes, K. Cell 154, 1140–1150 (2013).
Veening, J.-W., Smits, W. K. & Kuipers, O. P. Annu. Rev. Microbiol. 62, 193–210 (2008).
Pu, Y. et al. Mol. Cell 62, 284–294 (2016).
Maisonneuve, E., Shakespeare, L. J., Jørgensen, M. G. & Gerdes, K. Proc. Natl Acad. Sci. USA 108, 13206–13211 (2011).
Helaine, S. et al. Science 343, 204–208 (2014).
Verstraeten, N. et al. Mol. Cell. 59, 9–21 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Gerdes, K., Semsey, S. Pumping persisters. Nature 534, 41–42 (2016). https://doi.org/10.1038/nature18442
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature18442
This article is cited by
-
Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells
Scientific Reports (2019)
-
Persister Cells – a Plausible Outcome of Neutral Coevolutionary Drift
Scientific Reports (2018)
