Letter | Published:

Universality of human microbial dynamics

Nature volume 534, pages 259262 (09 June 2016) | Download Citation

Abstract

Human-associated microbial communities have a crucial role in determining our health and well-being1,2, and this has led to the continuing development of microbiome-based therapies3 such as faecal microbiota transplantation4,5. These microbial communities are very complex, dynamic6 and highly personalized ecosystems3,7, exhibiting a high degree of inter-individual variability in both species assemblages8 and abundance profiles9. It is not known whether the underlying ecological dynamics of these communities, which can be parameterized by growth rates, and intra- and inter-species interactions in population dynamics models10, are largely host-independent (that is, universal) or host-specific. If the inter-individual variability reflects host-specific dynamics due to differences in host lifestyle11, physiology12 or genetics13, then generic microbiome manipulations may have unintended consequences, rendering them ineffective or even detrimental. Alternatively, microbial ecosystems of different subjects may exhibit universal dynamics, with the inter-individual variability mainly originating from differences in the sets of colonizing species7,14. Here we develop a new computational method to characterize human microbial dynamics. By applying this method to cross-sectional data from two large-scale metagenomic studies—the Human Microbiome Project9,15 and the Student Microbiome Project16—we show that gut and mouth microbiomes display pronounced universal dynamics, whereas communities associated with certain skin sites are probably shaped by differences in the host environment. Notably, the universality of gut microbial dynamics is not observed in subjects with recurrent Clostridium difficile infection17 but is observed in the same set of subjects after faecal microbiota transplantation. These results fundamentally improve our understanding of the processes that shape human microbial ecosystems, and pave the way to designing general microbiome-based therapies18.

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Acknowledgements

We thank E. K. Silverman, G. Weinstock, C. Huttenhower, R. Knight, G. Ackermann, D. Del Vecchio, D. Lauffenburger, G. Abu-Ali, J. Sordillo, M. McGeachie, and J. Gore for discussions. Special thanks to A.-L. Barabási and J. Loscalzo for careful reading of the manuscript. This work was partially supported by the John Templeton Foundation (award number 51977) and National Institutes of Health (R01 HL091528).

Author information

Affiliations

  1. Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

    • Amir Bashan
    • , Travis E. Gibson
    • , Vincent J. Carey
    • , Scott T. Weiss
    •  & Yang-Yu Liu
  2. Physics of Living Systems, Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA

    • Jonathan Friedman
  3. Infectious Disease Division, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA

    • Elizabeth L. Hohmann
  4. Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA

    • Yang-Yu Liu

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Contributions

Y.-Y.L. conceived and designed the project. A.B. developed the DOC analysis, performed numerical simulations, and analysed all the real data. A.B. and Y.-Y.L. performed analytical calculations. A.B. and V.J.C. performed statistical tests. All authors analysed the results. A.B. and Y.-Y.L. wrote the manuscript. All authors edited the manuscript.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Yang-Yu Liu.

Reviewer Information Nature thanks F. He, P. Rohani and the other anonymous reviewer(s) for their contribution to the peer review of this work.

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    Supplementary Information

    This file contains Supplementary Text and Data, Supplementary Tables 1-4 and additional references.

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    Supplementary Data

    This zipped file contains the source code of the DOC method.

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DOI

https://doi.org/10.1038/nature18301

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