Extended Data Figure 1: The metabolic transformations of ketamine in vivo. | Nature

Extended Data Figure 1: The metabolic transformations of ketamine in vivo.

From: NMDAR inhibition-independent antidepressant actions of ketamine metabolites

Extended Data Figure 1

Ketamine is metabolised in vivo via P450 enzymatic transformations. i, (R,S)-KET is selectively demethylated to give (R,S)-norketamine (norKET). ii, NorKET can be then dehydrogenated to give (R,S)-dehydronorketamine (DHNK). iii, Alternatively, norKET can be hydroxylated to give the hydroxynorketamines (HNKs). iv, (R,S)-KET can also be hydroxylated at the 6 position to give either the E-6-hydroxyketamine ((2S,6R;2R,6S)-HK) or Z-6-hydroxyketamine ((2S,6S;2R,6R)-HK). v, Demethylation of (2S,6R;2R,6S)-HK yields the production of (2S,6R;2R,6S)-HNK. vi, Demethylation of (2S,6S;2R,6R)-HK further gives (2S,6S;2R,6R)-HNK.

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