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Limb regrowth takes two

Salamanders can regenerate several of their organs, including amputated limbs. Analysis of a Mexican salamander shows that crosstalk between two signalling molecules regulates limb regeneration. See Letter p.407

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Figure 1: Complementary signals promote limb regeneration.


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  1. Dinsmore, C. E. Int. J. Dev. Biol. 40, 621–627 (1996).

    CAS  PubMed  Google Scholar 

  2. Bryant, S. V. Nature 263, 676–679 (1976).

    Article  ADS  CAS  Google Scholar 

  3. Nacu, E., Gromberg, E., Oliveira, C., Drechsel, D. & Tanaka, E. M. Nature 533, 407–410 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Nacu, E. & Tanaka, E. M. Annu. Rev. Cell Dev. Biol. 27, 409–440 (2011).

    Article  CAS  Google Scholar 

  5. Singer, M. Q. Rev. Biol. 27, 169–200 (1952).

    Article  CAS  Google Scholar 

  6. Lheureux, E. J. Embryol. Exp. Morphol. 38, 151–173 (1977).

    CAS  PubMed  Google Scholar 

  7. Meinhardt, H. J. Embryol. Exp. Morphol. 76, 115–137 (1983).

    CAS  PubMed  Google Scholar 

  8. Niswander, L., Jeffrey, S., Martin, G. R. & Tickle, C. Nature 371, 609–612 (1994).

    Article  ADS  CAS  Google Scholar 

  9. Zúñiga, A., Haramis, A.-P. G., McMahon, A. P. & Zeller, R. Nature 401, 598–602 (1999).

    Article  ADS  Google Scholar 

  10. Sugiura, T., Wang, H., Barsacchi, R., Simon, A. & Tanaka, E. M. Nature 531, 237–240 (2016).

    Article  ADS  CAS  Google Scholar 

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Correspondence to Miguel Torres.

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Torres, M. Limb regrowth takes two. Nature 533, 328–330 (2016).

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