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Cell biology

Ubiquitination without E1 and E2 enzymes

A protein in the pathogenic bacterium Legionella pneumophila has been found to attach the modifying molecule ubiquitin to human proteins, using a mechanism that, surprisingly, does not involve cellular E1 and E2 enzymes. See Letter p.120

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Figure 1: Mechanisms of ubiquitination.

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Correspondence to Ivan Dikic.

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Bhogaraju, S., Dikic, I. Ubiquitination without E1 and E2 enzymes. Nature 533, 43–44 (2016). https://doi.org/10.1038/nature17888

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