Extended Data Figure 5: Conservation of residues in the MK-0893 bipartite allosteric pocket. | Nature

Extended Data Figure 5: Conservation of residues in the MK-0893 bipartite allosteric pocket.

From: Extra-helical binding site of a glucagon receptor antagonist

Extended Data Figure 5

a, Sequence alignment of 15 human GPCR class B members across residues constituting the MK-0893 bipartite binding site. UniProt accession numbers are given. b, The GCGR MK-0893 allosteric binding site is shown in surface representation with residues in a coloured in rainbow spectrum according to conservation level (red = 100%; blue = 0%). MK-0893 is in stick representation with carbon, nitrogen, oxygen and chlorine atoms coloured purple, blue, red and green, respectively.

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