Extended Data Figure 1: Packing interactions in the GCGR-StaR(136–417)–T4L primitive orthorhombic crystal system. | Nature

Extended Data Figure 1: Packing interactions in the GCGR-StaR(136–417)–T4L primitive orthorhombic crystal system.

From: Extra-helical binding site of a glucagon receptor antagonist

Extended Data Figure 1

a, View along b-axis, GCGR-StaR TMD in blue ribbon representation, T4L in magenta ribbon representation, MK-0893 in stick representation with carbon, nitrogen, oxygen and chlorine atoms coloured yellow, blue, red and green, respectively. b, View as in a rotated 90° to view along c-axis. c, Close-up of the hydrophobic/shape complementarity interaction of the dichlorophenyl ‘head’ group of MK-0893 with residues on TM4 of a symmetry-related copy.

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