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Molecular biology

Breaks in the brain

A high-throughput approach has found clusters of DNA double-strand breaks in neural cells. Most of the clusters are in large genes that are associated with neural function, which suggests that the breaks may have tissue-specific roles.

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Figure 1: Translocation hotspots.

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References

  1. Lee, J. A., Carvalho, C. M. B. & Lupski, J. R. Cell 131, 1235–1247 (2007).

    CAS  Article  Google Scholar 

  2. Wei, P.-C. et al. Cell 164, 644–655 (2016).

    CAS  Article  Google Scholar 

  3. Cai, X. et al. Cell Rep. 8, 1280–1289 (2014).

    CAS  Article  Google Scholar 

  4. McConnell, M. J. et al. Science 342, 632–637 (2013).

    ADS  CAS  Article  Google Scholar 

  5. Wilson, T. E. et al. Genome Res. 25, 189–200 (2015).

    CAS  Article  Google Scholar 

  6. Durkin, S. G. & Glover, T. W. Annu. Rev. Genet. 41, 169–192 (2007).

    CAS  Article  Google Scholar 

  7. Minocherhomji, S. et al. Nature 528, 286–290 (2015).

    ADS  CAS  Article  Google Scholar 

  8. Muotri, A. R. & Gage, F. H. Nature 441, 1087–1093 (2006).

    ADS  CAS  Article  Google Scholar 

  9. Hannibal, R. L. et al. PLoS Genet. 10, e1004290 (2014).

    Article  Google Scholar 

  10. O'Huallachain, M., Karczewski, K. J., Weissman, S. M., Urban, A. E. & Snyder, M. P. Proc. Natl Acad. Sci. USA 109, 18018–18023 (2012).

    ADS  CAS  Article  Google Scholar 

  11. Gao, Y. et al. Cell 95, 891–902 (1998).

    CAS  Article  Google Scholar 

  12. Gabel, H. W. et al. Nature 522, 89–93 (2015).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Thomas W. Glover or Thomas E. Wilson.

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Glover, T., Wilson, T. Breaks in the brain. Nature 532, 46–47 (2016). https://doi.org/10.1038/nature17316

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