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An elusive DNA base in mammals

The discovery of a modified version of the base adenine, known as N6-methyladenine, in mouse DNA puts paid to the theory that cytosine derivatives are the only modified bases in mammals. See Article p.329

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Figure 1: Methyl modification in mammals.


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  1. Wu, T. P. et al. Nature 532, 329–333 (2016).

    ADS  Article  CAS  Google Scholar 

  2. Bestor, T. H., Edwards, J. R. & Boulard, M. Proc. Natl Acad. Sci. USA 112, 6796–6799 (2015).

    ADS  Article  CAS  Google Scholar 

  3. Schübeler, D. Nature 517, 321–326 (2015).

    ADS  Article  CAS  Google Scholar 

  4. Pastor, W. A., Aravind, L. & Rao, A. Nature Rev. Mol. Cell Biol. 14, 341–356 (2013).

    Article  CAS  Google Scholar 

  5. Marinus, M. G. & Casadesus, J. FEMS Microbiol. Rev. 33, 488–503 (2009).

    Article  CAS  Google Scholar 

  6. Ratel, D., Ravanat, J. L., Berger, F. & Wion, D. BioEssays 28, 309–315 (2006).

    Article  CAS  Google Scholar 

  7. Fu, Y. et al. Cell 161, 879–892 (2015).

    Article  CAS  Google Scholar 

  8. Greer, E. L. et al. Cell 161, 868–878 (2015).

    Article  CAS  Google Scholar 

  9. Zhang, G. et al. Cell 161, 893–906 (2015).

    Article  CAS  Google Scholar 

  10. Murray, I. A. et al. Nucleic Acids Res. 40, 11450–11462 (2012).

    Article  CAS  Google Scholar 

  11. Zheng, G. et al. Mol. Cell 49, 18–29 (2013).

    Article  CAS  Google Scholar 

  12. Fedeles, B. I., Singh, V., Delaney, J. C., Li, D. & Essigmann, J. M. J. Biol. Chem. 290, 20734–20742 (2015).

    Article  CAS  Google Scholar 

  13. Koziol, M. J. et al. Nature Struct. Mol. Biol. 23, 24–30 (2016).

    Article  CAS  Google Scholar 

  14. Iyer, L. M., Zhang, D. & Aravind, L. BioEssays 38, 27–40 (2016).

    Article  CAS  Google Scholar 

  15. Dunwell, T. L., McGuffin, L. J., Dunwell, J. M. & Pfeifer, G. P. Cell Cycle 12, 3357–3365 (2013).

    Article  CAS  Google Scholar 

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Correspondence to Gerd P. Pfeifer.

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Pfeifer, G. An elusive DNA base in mammals. Nature 532, 319–320 (2016).

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