Organelles called primary cilia that protrude from cells have been thought to sense the surrounding environment through calcium-channel proteins that respond to force. Two scientists discuss the implications for developmental biology and kidney disease of a study that challenges this hypothesis. See Letter p.656
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Delling, M. et al. Nature 531, 656–660 (2016).
Nonaka, S., Shiratori, H., Saijoh, Y. & Hamada, H. Nature 418, 96–99 (2002).
McGrath, J., Somlo, S., Makova, S., Tian, X. & Brueckner, M. Cell 114, 61–73 (2003).
Yoshiba, S. et al. Science 338, 226–231 (2012).
Yuan, S., Zhao, L., Brueckner, M. & Sun, Z. Curr. Biol. 25, 556–567 (2015).
Norris, D. P. BMC Biol 10, 102 (2012).
Schwander, M., Kachar, B. & Müller, U. J. Cell Biol. 190, 9–20 (2010).
Praetorius, H. A. & Spring, K. R. J. Membr. Biol. 184, 71–79 (2001).
Goetz, S. C. & Anderson, K. V. Nature Rev. Genet. 11, 331–344 (2010).
Hildebrandt, F., Benzing, T. & Katsanis, N. N. Engl. J. Med. 364, 1533–1543 (2011).
Delling, M., DeCaen, P. G., Doerner, J. F., Febvay, S. & Clapham, D. E. Nature 504, 311–314 (2013).
DeCaen, P. G., Delling, M., Vien, T. N. & Clapham, D. E. Nature 504, 315–318 (2013).
Author information
Authors and Affiliations
Corresponding authors
Related links
Related links
Related links in Nature Research
Rights and permissions
About this article
Cite this article
Norris, D., Jackson, P. Calcium contradictions in cilia. Nature 531, 582–583 (2016). https://doi.org/10.1038/nature17313
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature17313
This article is cited by
-
Pharmacological Regulation of Primary Cilium Formation Affects the Mechanosensitivity of Osteocytes
Calcified Tissue International (2020)
-
Cellular signalling by primary cilia in development, organ function and disease
Nature Reviews Nephrology (2019)
-
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
Nature Structural & Molecular Biology (2017)