Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Alzheimer's disease

Lost memories found

Enhancing synaptic connections between neurons in the brain's hippocampus that are normally activated during memory formation rescues memory deficits in a mouse model of early Alzheimer's disease. See Letter p.508

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: Light-induced rescue of episodic memory.


  1. See all news & views


  1. Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. Genet. Med. (2015).

  2. Terry, R. D. et al. Ann. Neurol. 30, 572–580 (1991).

    CAS  PubMed  Google Scholar 

  3. Roy, D. S. et al. Nature 531, 508–512 (2016).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  4. Tonegawa, S., Liu, X., Ramirez, S. & Redondo, R. Neuron 87, 918–931 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. Reijmers, L. G., Perkins, B. L., Matsuo, N. & Mayford, M. Science 317, 1230–1233 (2007).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Abel, T. & Lattal, K. M. Curr. Opin. Neurobiol. 11, 180–187 (2001).

    Article  CAS  PubMed  Google Scholar 

  7. Nguyen, P. V. & Kandel, E. R. J. Neurosci. 16, 3189–3198 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Nabavi, S. et al. Nature 511, 348–352 (2014).

    Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

  9. Cirrito, J. R. et al. Neuron 48, 913–922 (2005).

    Article  CAS  PubMed  Google Scholar 

  10. Leinenga, G. & Götz, J. Sci. Transl. Med. 7, 278ra33 (2015).

    Article  PubMed  Google Scholar 

  11. Joo, J.-Y., Schaukowitch, K., Farbiak, L., Kilaru, G. & Kim T.-K. Nature Neurosci. 19, 75–83 (2016).

    Article  CAS  PubMed  Google Scholar 

  12. Cazzulino, A. S., Martinez, R., Tomm, N.K. & Denny, C. A. Hippocampus (2015).

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Prerana Shrestha or Eric Klann.

Related links

Related links

Related links in Nature Research

Neuroscience: The power of positivity

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shrestha, P., Klann, E. Lost memories found. Nature 531, 450–451 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing