Enhancing synaptic connections between neurons in the brain's hippocampus that are normally activated during memory formation rescues memory deficits in a mouse model of early Alzheimer's disease. See Letter p.508
This is a preview of subscription content, access via your institution
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
Prices may be subject to local taxes which are calculated during checkout
Van Cauwenberghe, C., Van Broeckhoven, C. & Sleegers, K. Genet. Med. http://dx.doi.org/10.1038/gim.2015.117 (2015).
Terry, R. D. et al. Ann. Neurol. 30, 572–580 (1991).
Roy, D. S. et al. Nature 531, 508–512 (2016).
Tonegawa, S., Liu, X., Ramirez, S. & Redondo, R. Neuron 87, 918–931 (2015).
Reijmers, L. G., Perkins, B. L., Matsuo, N. & Mayford, M. Science 317, 1230–1233 (2007).
Abel, T. & Lattal, K. M. Curr. Opin. Neurobiol. 11, 180–187 (2001).
Nguyen, P. V. & Kandel, E. R. J. Neurosci. 16, 3189–3198 (1996).
Nabavi, S. et al. Nature 511, 348–352 (2014).
Cirrito, J. R. et al. Neuron 48, 913–922 (2005).
Leinenga, G. & Götz, J. Sci. Transl. Med. 7, 278ra33 (2015).
Joo, J.-Y., Schaukowitch, K., Farbiak, L., Kilaru, G. & Kim T.-K. Nature Neurosci. 19, 75–83 (2016).
Cazzulino, A. S., Martinez, R., Tomm, N.K. & Denny, C. A. Hippocampus http://dx.doi.org/10.1002/hipo.22556 (2015).
Related links in Nature Research
About this article
Cite this article
Shrestha, P., Klann, E. Lost memories found. Nature 531, 450–451 (2016). https://doi.org/10.1038/nature17312
This article is cited by
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation
Nature Neuroscience (2020)
Anti-diabetic vanadyl complexes reduced Alzheimer’s disease pathology independent of amyloid plaque deposition
Science China Life Sciences (2019)