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Cancer immunotherapy

Killers on sterols

Nature volume 531, pages 583–584 (2016)Cite this article

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Increasing cholesterol levels in the cell membranes of killer T cells boosts the cells' ability to mount an immune response against tumour cells in mice. Such a strategy might be valuable in anticancer immunotherapies. See Letter p.651

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Figure 1: Synergy at the immunological synapse.

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References

  1. Korman, A. J., Peggs, K. S. & Allison, J. P. Adv. Immunol. 90, 297–339 (2006).

    Article  CAS  Google Scholar 

  2. Porter, D. L., Levine, B. L., Kalos, M., Bagg, A. & June, C. H. N. Engl. J. Med. 365, 725–733 (2011).

    Article  CAS  Google Scholar 

  3. Yang, W. et al. Nature 531, 651–655 (2016).

    Article  ADS  CAS  Google Scholar 

  4. Xavier, R., Brennan, T., Li, Q., McCormack, C. & Seed, B. Immunity 8, 723–732 (1998).

    Article  CAS  Google Scholar 

  5. Buck, M. D., O'Sullivan, D. & Pearce, E. L. J. Exp. Med. 212, 1345–1360 (2015).

    Article  CAS  Google Scholar 

  6. Chang, T.-Y., Li, B.-L., Chang, C. C. Y. & Urano, Y. Am. J. Physiol. Endocrinol. Metab. 297, E1–E9 (2009).

    Article  ADS  CAS  Google Scholar 

  7. Mingueneau, M. et al. Nature Immunol. 14, 619–632 (2013).

    Article  CAS  Google Scholar 

  8. Dustin, M. L. Cancer Immunol. Res. 2, 1023–1033 (2014).

    Article  CAS  Google Scholar 

  9. Beal, A. M. et al. Immunity 31, 632–642 (2009).

    Article  CAS  Google Scholar 

  10. Lillemeier, B. F. et al. Nature Immunol. 11, 90–96 (2010).

    Article  CAS  Google Scholar 

  11. Tardif, J. C. et al. Circulation 110, 3372–3377 (2004).

    Article  CAS  Google Scholar 

  12. Yokosuka, T. et al. J. Exp. Med. 209, 1201–1217 (2012).

    Article  CAS  Google Scholar 

  13. Robert, C. et al. N. Engl. J. Med. 372, 320–330 (2015).

    Article  CAS  Google Scholar 

Download references

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  1. Michael L. Dustin is at the Kennedy Institute of Rheumatology, University of Oxford, Oxford OX3 7FY, UK.,

    Michael L. Dustin

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  1. Michael L. Dustin
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Correspondence to Michael L. Dustin.

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Dustin, M. Killers on sterols. Nature 531, 583–584 (2016). https://doi.org/10.1038/nature17310

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