Lack of the protein IRP2 in mice prevents organelles called mitochondria from accumulating toxic levels of iron in response to smoke exposure. This discovery links environmental and genetic risk factors for a chronic lung disease.
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References
Johnson, N. B., Hayes, L. D., Brown, K., Hoo, E. C. & Ethier, K. A. MMWR Suppl. 63 (Suppl. 4), 3–27 (2014).
Gordon, S. B. et al. Lancet Respir. Med. 2, 823–860 (2014).
Islam, J. Y., Keller, R. L., Aschner, J. L., Hartert, T. V. & Moore, P. E. Am. J. Respir. Crit. Care Med. 192, 134–156 (2015).
Weiss, S. T. Nature Genet. 42, 14–16 (2010).
Cloonan, S. M. et al. Nature Med. 22, 163–174 (2016).
Burrows, B., Knudson, R. J., Cline, M. G. & Lebowitz, M. D. Am. Rev. Respir. Dis. 115, 195–205 (1977).
Laurell, C.-B. & Eriksson, S. Scand. J. Clin. Lab. Invest. 15, 132–140 (1963).
Lieberman, J., Winter, B. & Sastre, A. Chest 89, 370–373 (1986).
Silverman, E. K. et al. Am. J. Hum. Genet. 70, 1229–1239 (2002).
DeMeo, D. L. et al. Am. J. Hum. Genet. 85, 493–502 (2009).
Ghio, A. J. Biochim. Biophys. Acta 1790, 731–739 (2009).
Chen, C. & Paw, B. H. Biochim. Biophys. Acta 1823, 1459–1467 (2012).
Aravamudan, B., Thompson, M. A., Pabelick, C. M. & Prakash, Y. S. Expert Rev. Respir. Med. 7, 631–646 (2013).
Dubey, S. & Powell, C. A. Am. J. Respir. Crit. Care Med. 179, 860–868 (2009).
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Mariani, T. Ironing out smoking-related airway disease. Nature 531, 586–587 (2016). https://doi.org/10.1038/nature17309
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DOI: https://doi.org/10.1038/nature17309
