Extended Data Figure 10 : SAMMSON silencing decreases melanoma growth in vivo.

From: Melanoma addiction to the long non-coding RNA SAMMSON

Extended Data Figure 10

a, Table describes the origin and BRAF, NRAS and TP53 mutational status of the melanoma lesions that were used to generate the Mel006 and Mel010 PDX models. b, Gene set enrichment analyses among differentially expressed genes in melanoma lesions obtained from Mel006 PDX mice treated (i.v. injections) with a control GapmeR (Ctrl) or GapmeR3. c, Tumour volume of cohorts of Mel010 PDX mice treated (intra-tumour injections) with a control GapmeR (Ctrl) or GapmeR3. Data are means ± s.d. of three different biological replicates (P value was calculated by two-ways ANOVA). d, Tumour weight of the melanoma lesions derived from PDX mice (Mel006) treated with combinations of control GapmeR (Ctrl) and GapmeR3 with either vehicle or dabrafenib by daily oral gavage (vehicle or dabrafenib) and i.v. injection of the GapmeRs every 2 days. P value was calculated by t-test.