Abstract
In eukaryotic cells, the endoplasmic reticulum is essential for the folding and trafficking of proteins that enter the secretory pathway. Environmental insults or increased protein synthesis often lead to protein misfolding in the organelle, the accumulation of misfolded or unfolded proteins — known as endoplasmic reticulum stress — and the activation of the adaptive unfolded protein response to restore homeostasis. If protein misfolding is not resolved, cells die. Endoplasmic reticulum stress and activation of the unfolded protein response help to determine cell fate and function. Furthermore, endoplasmic reticulum stress contributes to the aetiology of many human diseases.
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Acknowledgements
The authors apologize to those researchers whose references they were unable to acknowledge due to space limitations. R.J.K. is supported by US National Institutes of Health grants R37 DK042394, R01 DK088227, R01 DK103183 and CA128814.
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Wang, M., Kaufman, R. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature 529, 326–335 (2016). https://doi.org/10.1038/nature17041
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DOI: https://doi.org/10.1038/nature17041
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