Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Regeneration

Stem cells make the bowel nervous

Nature volume 531, pages 44–45 (2016)Cite this article

Subjects

In Hirschsprung disease, the enteric nervous system (ENS) is missing from the distal bowel. It emerges that postnatal transplantation of stem-cell-derived ENS precursors can prevent death in a mouse model of the disease. See Letter p.105

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Help for a model of Hirschsprung disease.

Notes

  1. See all news & views

References

  1. Kunze, W. A. A. & Furness, J. B. Annu. Rev. Physiol. 61, 117–142 (1999).

    Article  CAS  Google Scholar 

  2. McKeown, S. J., Stamp, L., Hao, M. M. & Young, H. M. Wiley Interdisc. Rev. Dev. Biol. 2, 113–129 (2013).

    Article  CAS  Google Scholar 

  3. Heuckeroth, R. O. in Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children (eds Faure, C., Di Lorenzo, C. & Thapar, N.) 271–283 (Springer, 2013).

    Book  Google Scholar 

  4. Burkardt, D. D., Graham, J. M., Short, S. S. & Frykman, P. K. Clin. Pediatr. 53, 71–81 (2014).

    Article  Google Scholar 

  5. Fattahi, F. et al. Nature 531, 105–109 (2016).

    Article  ADS  CAS  Google Scholar 

  6. Furness, J. B. Nature Rev. Gastroenterol. Hepatol. 9, 286–294 (2012).

    Article  CAS  Google Scholar 

  7. Neunlist, M. & Schemann, M. J. Physiol. (Lond.) 592, 2959–2965 (2014).

    Article  CAS  Google Scholar 

  8. Burns, A. J. & Thapar, N. Nature Rev. Gastroenterol. Hepatol. 11, 317–328 (2014).

    Article  Google Scholar 

  9. Metzger, M., Caldwell, C., Barlow, A. J., Burns, A. J. & Thapar, N. Gastroenterology 136, 2214–2225 (2009).

    Article  CAS  Google Scholar 

  10. Avetisyan, M., Schill, E. M. & Heuckeroth, R. O. J. Clin. Invest. 125, 899–907 (2015).

    Article  Google Scholar 

  11. Takahashi, K. & Yamanaka, S. Development 142, 3274–3285 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Robert O. Heuckeroth is at the Children's Hospital of Philadelphia Research Institute and the Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.,

    Robert O. Heuckeroth

Authors
  1. Robert O. Heuckeroth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert O. Heuckeroth.

Related links

Related links

Related links in Nature Research

Stem Cells: One step closer to gut repair

Neuroscience: Stem cells in multiple time zones

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Heuckeroth, R. Stem cells make the bowel nervous. Nature 531, 44–45 (2016). https://doi.org/10.1038/nature16877

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature16877

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing