The selective elimination of cells that have adopted an irreversible, senescent state has now been shown to extend the lifespan of mice and to ameliorate some age-related disease processes. See Article p.184
Your institute does not have access to this article
Access options
Subscribe to Journal
Get full journal access for 1 year
$199.00
only $3.90 per issue
All prices are NET prices.
VAT will be added later in the checkout.
Tax calculation will be finalised during checkout.
Buy article
Get time limited or full article access on ReadCube.
$32.00
All prices are NET prices.

Notes
References
Hayflick, L. Exp. Cell Res. 37, 614–636 (1965).
Baker, D. J. et al. Nature 530, 184–189 (2016).
Muñoz-Espin, D. & Serrano, M. Nature Rev. Mol. Cell Biol. 15, 482–496 (2014).
Baker, D. J. et al. Nature 479, 232–236 (2011).
van Deursen, J. M. Nature 509, 439–446 (2014).
Zhu, Y. et al. Aging Cell 14, 644–658 (2015).
Chang, J. et al. Nature Med. 22, 78–83 (2016).
Xu, M. et al. Proc. Natl Acad. Sci. USA 112, E6301–E6310 (2015).
Harrison, D. E. et al. Nature 460, 392–395 (2009).
Herranz, N. et al. Nature Cell Biol. 17, 1205–1217 (2015).
Laberge, R. M. et al. Nature Cell Biol. 17, 1049–1061 (2015).
Author information
Authors and Affiliations
Corresponding author
Related links
Rights and permissions
About this article
Cite this article
Gil, J., Withers, D. Out with the old. Nature 530, 164–165 (2016). https://doi.org/10.1038/nature16875
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature16875
Further reading
-
The ageing epigenome and its rejuvenation
Nature Reviews Molecular Cell Biology (2020)
-
Killing the old: cell senescence in atherosclerosis
Nature Reviews Cardiology (2017)