Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Out with the old


The selective elimination of cells that have adopted an irreversible, senescent state has now been shown to extend the lifespan of mice and to ameliorate some age-related disease processes. See Article p.184

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Improving healthspan.


  1. See all news & views


  1. Hayflick, L. Exp. Cell Res. 37, 614–636 (1965).

    Article  CAS  Google Scholar 

  2. Baker, D. J. et al. Nature 530, 184–189 (2016).

    Article  ADS  CAS  Google Scholar 

  3. Muñoz-Espin, D. & Serrano, M. Nature Rev. Mol. Cell Biol. 15, 482–496 (2014).

    Article  Google Scholar 

  4. Baker, D. J. et al. Nature 479, 232–236 (2011).

    Article  ADS  CAS  Google Scholar 

  5. van Deursen, J. M. Nature 509, 439–446 (2014).

    Article  ADS  CAS  Google Scholar 

  6. Zhu, Y. et al. Aging Cell 14, 644–658 (2015).

    Article  CAS  Google Scholar 

  7. Chang, J. et al. Nature Med. 22, 78–83 (2016).

    Article  ADS  CAS  Google Scholar 

  8. Xu, M. et al. Proc. Natl Acad. Sci. USA 112, E6301–E6310 (2015).

    Article  CAS  Google Scholar 

  9. Harrison, D. E. et al. Nature 460, 392–395 (2009).

    Article  ADS  CAS  Google Scholar 

  10. Herranz, N. et al. Nature Cell Biol. 17, 1205–1217 (2015).

    Article  CAS  Google Scholar 

  11. Laberge, R. M. et al. Nature Cell Biol. 17, 1049–1061 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Dominic J. Withers.

Related links

Related links

Related links in Nature Research

Ageing: Old cells under attack

Ageing: Genetic rejuvenation of old muscle

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gil, J., Withers, D. Out with the old. Nature 530, 164–165 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing