The native structure of the protein α-synuclein, which is implicated in Parkinson's disease, is controversial. In-cell nuclear magnetic resonance now shows that it remains disordered when loaded into living cells. See Article p.45
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Alderson, T., Bax, A. Disorder in the court. Nature 530, 38–39 (2016). https://doi.org/10.1038/nature16871
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DOI: https://doi.org/10.1038/nature16871