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Parkinson's disease

Disorder in the court

The native structure of the protein α-synuclein, which is implicated in Parkinson's disease, is controversial. In-cell nuclear magnetic resonance now shows that it remains disordered when loaded into living cells. See Article p.45

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Figure 1: Structure of a disordered protein in living cells.


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  1. Fauvet, B. et al. J. Biol. Chem. 287, 15345–15364 (2012).

    CAS  Article  Google Scholar 

  2. Bartels, T., Choi, J. G. & Selkoe, D. J. Nature 477, 107–110 (2011).

    ADS  CAS  Article  Google Scholar 

  3. Dettmer, U. et al. Nature Commun. 6, 7314 (2015).

    ADS  Article  Google Scholar 

  4. Alderson, T. R. & Markley, J. L. Intrins. Disord. Proteins 1, 18–39 (2013).

    Article  Google Scholar 

  5. Theillet, F.-X. et al. Nature 530, 45–50 (2016).

    ADS  CAS  Article  Google Scholar 

  6. Sakakibara, D. et al. Nature 458, 102–105 (2009).

    ADS  CAS  Article  Google Scholar 

  7. Freedberg, D. I. & Selenko, P. Annu. Rev. Biophys. 43, 171–192 (2014).

    CAS  Article  Google Scholar 

  8. Lashuel, H. A., Overk, C. R., Oueslati, A. & Masliah, E. Nature Rev. Neurosci. 14, 38–48 (2013).

    CAS  Article  Google Scholar 

  9. Burré, J. et al. Science 329, 1663–1667 (2010).

    ADS  Article  Google Scholar 

  10. Luth, E. S., Bartels, T., Dettmer, U., Kim, N. C. & Selkoe, D. J. Biochemistry 54, 279–292 (2015).

    CAS  Article  Google Scholar 

  11. Burré, J., Sharma, M. & Südhof, T. C. Proc. Natl Acad. Sci. USA 111, E4274–E4283 (2014).

    ADS  Article  Google Scholar 

  12. Binolfi, A. et al. Nature Commun. http://dx.doi/10.1038/ncomms10251 (2016).

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Correspondence to T. Reid Alderson or Ad Bax.

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Alderson, T., Bax, A. Disorder in the court. Nature 530, 38–39 (2016).

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