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Bet on drug resistance

Inhibitors of the BET bromodomain proteins are promising cancer therapeutics, but tumour cells are likely to become resistant to these drugs. Anticipated mechanisms of resistance have now been described. See Letter p.413

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Figure 1: Circumventing BET inhibition.


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Correspondence to Jeff Settleman.

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Settleman, J. Bet on drug resistance. Nature 529, 289–290 (2016).

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