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Bet on drug resistance

Inhibitors of the BET bromodomain proteins are promising cancer therapeutics, but tumour cells are likely to become resistant to these drugs. Anticipated mechanisms of resistance have now been described. See Letter p.413

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Figure 1: Circumventing BET inhibition.


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  1. Klijn, C. et al. Nature Biotechnol. 33, 306–312 (2015).

    Article  CAS  Google Scholar 

  2. Lackner, M. R., Wilson, T. R. & Settleman, J. Future Oncol. 8, 999–1014 (2012).

    Article  CAS  Google Scholar 

  3. Baylin, S. B. & Jones, P. A. Nature Rev. Cancer 11, 726–734 (2011).

    Article  CAS  Google Scholar 

  4. Rathert, P. et al. Nature 525, 543–547 (2015).

    Article  ADS  CAS  Google Scholar 

  5. Fong, C. Y. et al. Nature 525, 538–542 (2015).

    Article  ADS  CAS  Google Scholar 

  6. Shu, S. et al. Nature 529, 413–417 (2016).

    Article  ADS  CAS  Google Scholar 

  7. Eilers, M. & Eisenman, R. N. Genes Dev. 22, 2755–2766 (2008).

    Article  CAS  Google Scholar 

  8. Qi, J. Cold Spring Harb. Perspect. Biol. 6, a018663 (2014).

    Article  Google Scholar 

  9. Wang, Y. et al. Science 327, 1650–1653 (2010).

    Article  ADS  CAS  Google Scholar 

  10. Singh, A. & Settleman, J. Oncogene 29, 4741–4751 (2010).

    Article  CAS  Google Scholar 

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Correspondence to Jeff Settleman.

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Settleman, J. Bet on drug resistance. Nature 529, 289–290 (2016).

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