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Control of proteasomal proteolysis by mTOR


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Figure 1: Pulse-chase methodology using 3H-Phe allows valid measurements of degradation rates and shows that mTOR inhibition causes rapid and sustained increases in protein degradation by both proteasomal and lysosomal pathways in Tsc2-null MEFs.


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Correspondence to Alfred L. Goldberg.

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Zhao, J., Garcia, G. & Goldberg, A. Control of proteasomal proteolysis by mTOR. Nature 529, E1–E2 (2016).

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