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Control of proteasomal proteolysis by mTOR

Nature volume 529, pages E1–E2 (2016)Cite this article

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ARISING FROM Y. Zhang et al. Nature 513, 440–443 (2014); doi:10.1038/nature13492

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Figure 1: Pulse-chase methodology using 3H-Phe allows valid measurements of degradation rates and shows that mTOR inhibition causes rapid and sustained increases in protein degradation by both proteasomal and lysosomal pathways in Tsc2-null MEFs.

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Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Jinghui Zhao & Alfred L. Goldberg

  2. Department of Chemistry, Cambridge University, Cambridge CB2 1EW, UK,

    Gonzalo A. Garcia

Authors
  1. Jinghui Zhao
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  2. Gonzalo A. Garcia
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  3. Alfred L. Goldberg
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Correspondence to Alfred L. Goldberg.

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Zhao, J., Garcia, G. & Goldberg, A. Control of proteasomal proteolysis by mTOR. Nature 529, E1–E2 (2016). https://doi.org/10.1038/nature16472

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