The cellular process of autophagy has been proposed to help kill Mycobacterium tuberculosis. But although the autophagy gene Atg5 is key to host immunity, other autophagy genes do not affect the outcome of tuberculosis. See Letter p.565
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages
Nature Microbiology Open Access 23 March 2023
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Notes
References
Kimmey, J. M. et al. Nature 528, 565–569 (2015).
Bhatt, K. & Salgame, P. J. Clin. Immunol. 27, 347–362 (2007).
Liu, P. T., Stenger, S., Tang, D. H. & Modlin, R. L. J. Immunol. 179, 2060–2063 (2007).
Fabri, M. et al. Sci. Transl. Med. 3, 104ra102 (2011).
Fabri, M. & Modlin, R. L. Cell Host Microbe 6, 201–203 (2009).
Gutierrez, M. G. et al. Cell 119, 753–766 (2004).
Castillo, E. F. et al. Proc. Natl Acad. Sci. USA 109, E3168–E3176 (2012).
Watson, R. O., Manzanillo, P. S. & Cox, J. S. Cell 150, 803–815 (2012).
Chang, T. K. et al. Nature Cell Biol. 15, 1067–1078 (2013).
Nishida, Y. et al. Nature 461, 654–658 (2009).
Deretic, V., Jiang, S. & Dupont, N. Trends Cell Biol. 22, 397–406 (2012).
Shravage, B. V., Hill, J. H., Powers, C. M., Wu, L. & Baehrecke, E. H. Development 140, 1321–1329 (2013).
Sanjuan, M. A. et al. Nature 450, 1253–1257 (2007).
Behrends, C., Sowa, M. E., Gygi, S. P. & Harper, J. W. Nature 466, 68–76 (2010).
Yousefi, S. et al. Nature Cell Biol. 8, 1124–1132 (2006).
Young, M. M. et al. J. Biol. Chem. 287, 12455–1468 (2012).
Author information
Authors and Affiliations
Corresponding authors
Related links
Rights and permissions
About this article
Cite this article
Behar, S., Baehrecke, E. Autophagy is not the answer. Nature 528, 482–483 (2015). https://doi.org/10.1038/nature16324
Published:
Issue Date:
DOI: https://doi.org/10.1038/nature16324
This article is cited by
-
ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages
Nature Microbiology (2023)
-
Autophagy restricts Mycobacterium tuberculosis during acute infection in mice
Nature Microbiology (2023)
-
Autophagy is part of the answer to tuberculosis
Nature Microbiology (2023)
-
The crosstalk between bacteria and host autophagy: host defense or bacteria offense
Journal of Microbiology (2022)
-
Molecular basis of mycobacterial survival in macrophages
Cellular and Molecular Life Sciences (2017)