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Tuberculosis

Autophagy is not the answer

The cellular process of autophagy has been proposed to help kill Mycobacterium tuberculosis. But although the autophagy gene Atg5 is key to host immunity, other autophagy genes do not affect the outcome of tuberculosis. See Letter p.565

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Figure 1: Defence against Mycobacterium.

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Correspondence to Samuel M. Behar or Eric H. Baehrecke.

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Behar, S., Baehrecke, E. Autophagy is not the answer. Nature 528, 482–483 (2015). https://doi.org/10.1038/nature16324

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