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Experimental mismatch in neural circuits


The finding that acute and chronic manipulations of the same neural circuit can produce different behavioural outcomes poses new questions about how best to analyse these circuits. See Article p.358

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Figure 1: Mixed messages from neural manipulations.


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  1. 1

    Emiliani, V., Cohen, A. E., Deisseroth, K. & Häusser, M. J. Neurosci. 35, 13917–13926 (2015).

    CAS  Article  PubMed  Google Scholar 

  2. 2

    Otchy, T. M. et al. Nature 528, 358–363 (2015).

    ADS  CAS  Article  PubMed  Google Scholar 

  3. 3

    Kawai, R. et al. Neuron 86, 800–812 (2015).

    CAS  Article  PubMed  Google Scholar 

  4. 4

    Johansen, J. P., Wolff, S. B., Lüthi, A. & LeDoux, J. E. Biol. Psychiatry 71, 1053–1060 (2012).

    Article  PubMed  Google Scholar 

  5. 5

    Squire, L. R., Genzel, L., Wixted, J. T. & Morris, R. G. Cold Spring Harb. Perspect. Biol. 7, a021766 (2015).

    Article  PubMed  Google Scholar 

  6. 6

    Rothwell, P. E. et al. Cell 158, 198–212 (2014).

    CAS  Article  PubMed  Google Scholar 

  7. 7

    Buetfering, C., Allen, K. & Monyer, H. Nature Neurosci. 17, 710–718 (2014).

    CAS  Article  PubMed  Google Scholar 

  8. 8

    Chaumont, J. et al. Proc. Natl Acad. Sci. USA 110, 16223–16228 (2013).

    ADS  CAS  Article  PubMed  Google Scholar 

  9. 9

    Kravitz, A. V., Owen, S. F. & Kreitzer, A. C. Brain Res. 1511, 21–32 (2013).

    CAS  Article  PubMed  Google Scholar 

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Correspondence to Thomas C. Südhof.

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Südhof, T. Experimental mismatch in neural circuits. Nature 528, 338–339 (2015).

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