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Cure by killing

Two bi-specific protein constructs have been designed that direct the body's T cells to kill HIV-infected cells. The feat provides a step on the path to removing the latent virus reservoir that persists in patients on antiretroviral therapy.

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Figure 1: Bi-specific constructs.


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  1. Sung, J. A. M. et al. J. Clin. Invest. 125, 4077–4090 (2015).

    Article  Google Scholar 

  2. Pegu, A. et al. Nature Commun. 6, 8447 (2015).

    ADS  CAS  Article  Google Scholar 

  3. Archin, N. M. et al. Nature 487, 482–485 (2012).

    ADS  CAS  Article  Google Scholar 

  4. Elliott, J. H. et al. PLoS Pathog. 10, e1004473 (2014).

    Article  Google Scholar 

  5. Rasmussen, T. A. et al. Lancet HIV 1, e13–e21 (2014).

    Article  Google Scholar 

  6. Deng, K. et al. Nature 517, 381–385 (2015).

    ADS  CAS  Article  Google Scholar 

  7. Berg, J. et al. Proc. Natl Acad. Sci. USA 88, 4723–4727 (1991).

    ADS  CAS  Article  Google Scholar 

  8. Traunecker, A., Lanzavecchia, A. & Karjalainen, K. EMBO J. 10, 3655–3659 (1991).

    CAS  Article  Google Scholar 

  9. Bargou, R. et al. Science 321, 974–977 (2008).

    ADS  CAS  Article  Google Scholar 

  10. Richman, D. D. et al. Science 323, 1304–1307 (2009).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Douglas D. Richman.

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Richman, D. Cure by killing. Nature 528, 198–199 (2015).

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