Two studies provide evidence that epithelial tumour cells do not need to transition to a mesenchymal-cell state to form metastases, but that this process does contribute to drug resistance. See Article p.472 & Letter p.525
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Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Cell 139, 871–890 (2009).
Ye, X. & Weinberg, R. A. Trends Cell Biol. 25, 675–686 (2015).
Fischer, K. R. et al. Nature 527, 472–476 (2015).
Zheng, X. et al. Nature 527, 525–530 (2015).
Yu, M. et al. Science 339, 580–584 (2013).
Singh, A. & Settleman, J. E Oncogene 29, 4741–4751 (2010).
Peinado, H., Olmeda, D. & Cano, A. Nature Rev. Cancer 7, 415–428 (2007).
Puisieux, A., Brabletz, T. & Caramel, J. Nature Cell Biol. 16, 488–494 (2014).
Clark, A. G. & Vignjevic, D. M. Curr. Opin. Cell Biol. 36, 13–22 (2015).
Aceto, N. et al. Cell 158, 1110–1122 (2014).
Rumman, M., Dhawan, J. & Kassem, M. Stem Cells 33, 2903–2912 (2015).
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Maheswaran, S., Haber, D. Transition loses its invasive edge. Nature 527, 452–453 (2015). https://doi.org/10.1038/nature16313
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