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Cell fate

Transition loses its invasive edge

Two studies provide evidence that epithelial tumour cells do not need to transition to a mesenchymal-cell state to form metastases, but that this process does contribute to drug resistance. See Article p.472 & Letter p.525

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Figure 1: Metastatic potential.

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Correspondence to Shyamala Maheswaran or Daniel A. Haber.

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Maheswaran, S., Haber, D. Transition loses its invasive edge. Nature 527, 452–453 (2015). https://doi.org/10.1038/nature16313

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