Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell fate

Transition loses its invasive edge

Two studies provide evidence that epithelial tumour cells do not need to transition to a mesenchymal-cell state to form metastases, but that this process does contribute to drug resistance. See Article p.472 & Letter p.525

Your institute does not have access to this article

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Metastatic potential.


  1. See all news & views


  1. Thiery, J. P., Acloque, H., Huang, R. Y. & Nieto, M. A. Cell 139, 871–890 (2009).

    CAS  Article  Google Scholar 

  2. Ye, X. & Weinberg, R. A. Trends Cell Biol. 25, 675–686 (2015).

    CAS  Article  Google Scholar 

  3. Fischer, K. R. et al. Nature 527, 472–476 (2015).

    ADS  CAS  Article  Google Scholar 

  4. Zheng, X. et al. Nature 527, 525–530 (2015).

    ADS  CAS  Article  Google Scholar 

  5. Yu, M. et al. Science 339, 580–584 (2013).

    ADS  CAS  Article  Google Scholar 

  6. Singh, A. & Settleman, J. E Oncogene 29, 4741–4751 (2010).

    CAS  Article  Google Scholar 

  7. Peinado, H., Olmeda, D. & Cano, A. Nature Rev. Cancer 7, 415–428 (2007).

    CAS  Article  Google Scholar 

  8. Puisieux, A., Brabletz, T. & Caramel, J. Nature Cell Biol. 16, 488–494 (2014).

    CAS  Article  Google Scholar 

  9. Clark, A. G. & Vignjevic, D. M. Curr. Opin. Cell Biol. 36, 13–22 (2015).

    CAS  Article  Google Scholar 

  10. Aceto, N. et al. Cell 158, 1110–1122 (2014).

    CAS  Article  Google Scholar 

  11. Rumman, M., Dhawan, J. & Kassem, M. Stem Cells 33, 2903–2912 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Shyamala Maheswaran or Daniel A. Haber.

Related links

Related links

Related links in Nature Research

Cancer: The to and fro of tumour spread

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Maheswaran, S., Haber, D. Transition loses its invasive edge. Nature 527, 452–453 (2015).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing