Extended Data Figure 2: Mice that overexpress a human MECP2 transgene over a floxed Mecp2 allele show characteristic behavioural deficits. | Nature

Extended Data Figure 2: Mice that overexpress a human MECP2 transgene over a floxed Mecp2 allele show characteristic behavioural deficits.

From: Reversal of phenotypes in MECP2 duplication mice using genetic rescue or antisense oligonucleotides

Extended Data Figure 2

a, Flox;TG mice displayed hypoactivity and anxiety in the open field test similar to transgenic mice. b, Flox;TG mice showed heightened anxiety-like behaviour in the elevated plus maze test. c, Flox;TG mice showed enhanced motor learning in the rotarod test similar to transgenic mice (n = 18 for wild-type group; n = 9 for transgenic group; n = 14 for Flox group; n = 12 for Flox;TG group (for all behavioural tests)). Data were analysed by one-way ANOVA, with the exception of the rotarod test that was analysed by two-way ANOVA repeated measures followed by Tukey HSD post hoc correction for multiple comparisons. Data are mean ± s.e.m. *P < 0.05; **P < 0.01; ***P < 0.001.

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