Figure 1: Regulatory T cells impair metabolic regulation in old fat. | Nature

Figure 1: Regulatory T cells impair metabolic regulation in old fat.

From: Inflammation keeps old mice healthy

Figure 1

a, During ageing, immune cells called fat-resident regulatory T (fTreg) cells accumulate in body fat and decrease local inflammation (red colouring). This age-associated accumulation correlates with increases in metabolic dysregulation and in the size of the fat cells, and with a decrease in the ability of fat to remodel — the process by which fat undergoes morphological alterations in response to changing nutrient demands. b, Bapat et al.2 depleted the fTreg population in ageing mice. This increased inflammation, reduced the size of fat cells and improved fat remodelling, thereby improving metabolic regulation.

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